INDAPAMIDE ACTION MECHANISM Indapamide blocks slow component of delayed rectifier potassium current (IKs) without altering rapid component (IKr).Indapamide specifically blocks or antagonizes KCNQ1 and KCNE1 proteins action. Indapamide is also thought to stimulate synthesis of vasodilatory hypotensive prostaglandin (PGE2). INDAPAMIDE DOSAGE Indapami..